Moderna

Patient is an 18 year old female with no PMHx that presented with lightheadedness and three subsequent episodes of syncope approximately 3-10 minutes post-vaccination. Patient was found to have an abrasion to the outer corner of her right eyebrow following an unwitnessed. It was unknown if patient was seated or standing at the time. The nurse first on scene states the patient lost consciousness briefly again and experienced approximately 10 seconds of upper extremity muscle contractions (described as convulsions). Patient experienced a loss of bladder control upon loss of consciousness. Patient was lowered to the ground to be in a supine position by healthcare staff. At this time, patient was alert and oriented without agitation or confusion. Patient denies memory of the event. She states she had prior episodes of fainting after blood draw. Patient has no allergies to medication or food. No past surgical history. No prior hospitalizations. Denies personal and family history seizure disorders, cardiac disturbances, and hypoglycemic or hyperglycemic events. Patient was hooked up to cardiac monitor and found to be in normal sinus rhythm with a heart rate of 64bpm. Vitals Orthostatic BP measurements Lying supine - 110/72 Seated - 124/76 Standing - 128/72 HR: 64 bpm RR: 16 breaths/min without distress SO2: 99% On examination, patient was A&Ox3 without lethargy, agitation, or confusion. Patient has an abrasion to the superior aspect of the right orbit (outer eyebrow) without laceration or bleeding. Patient was diaphoretic and pale following event. Normal cardiac rate and rhythm. Radial pulses intact, strong and equal bilaterally. No obvious nystagmus. Upon standing, patient steady on her feet without abnormal gait.

Pt developed fevers > 103F, severe headache, transaminitis, hypoxia (ultimately requiring 7L/min O2 via nasal cannula), and severe pancytopenia resulting in hospitalization and a bone marrow biopsy w/ flow cytometry (ultimately negative for leukemia/lymphoma). Her symptoms improved with IV decadron> oral prednisone, though cytopenias are now recurring 4/14/21. Pt had a positive ANA to 2.72 (but was taking doxycycline for anaplasmosis- now PCR and AB titers are negative for Anaplasma) and a positive ENA AB, Anti-Ro is high at 8.0. She has no family hx of autoimmune disease. Her infectious work-up for HIV, EBV, CMV, Blastomycosis, Histoplasmosis, Coccidioides, tickborne pathogens, & ricketsial disease is negative.

Within 5 minutes of vaccine administration patient began to feel lightheaded and passed out in waiting room. Patient lost consciousness several times for intervals of one minute or less. Patient was very sweaty and urinated on herself. We called EMS who took patient to local hospital.

Within minutes (less than 5), patient began to faint and become extremely diaphoretic. Patient also lost control of her bladder and urinated while sitting in the chair. We immediately called 911 who stated not to move her our of the chair. Patient went in and out of consciousness several times (2-3) for short intervals (15-30 seconds). EMS arrived within 10 minutes of symptom onset and took her to the local hospital. While EMS was evaluating the patient in the pharmacy, she stated that she was beginning to have trouble breathing; but those symptoms quickly resolved without the administration of epinephrine. We received a phone call from the patient within 2 hours stating that she was being discharged from the hospital and was feeling much better.

8 days following the first Covid vaccine administration, patient started with vaginal bleeding that persists until today unless maintained on high dose oral contraceptives. She is currently under the care of a gynecologist who is trying to manage her symptoms.

Pt. reports that she noticed her left arm where she received Moderna COVID- 19 Vaccine EUA was red, swollen and itching this morning (01/06/2021) at approximately 7:45 AM. Pt. also states that she started taking Bactrim on 01/05/2021 for a UTI and she took only one dose prior to the event. Reports taking Amoxicillian for stye last week and was switched to Bactrim on Monday for a UTI but did not take first dose of Bactrim until Tuesday 01/05/2021. Pt. also reports all over itching including legs and face it red and blotchy on both cheeks that also began today. Pt. came into clinic on 01/06/2021 at 1:54 PM for visual evaluation of arm. Upper outer left arm (left deltoid area) has red rash 55MM Length & 30 MM Wide Area is also warm to touch. Pt. used cool compress for the redness, swelling and Benadryl for the itching.Pt. reports that swelling and redness has improved but itching continues along with aching. Reports a numb feeling in the area of the shot on left deltoid. Pt. also reports left axillary tenderness but states that started shortly after vaccination. Patient's mother notified primary care provider due to current use of Bactrim but no actual visit to doctor was made. Pt. instructed to continue to monitor for side effects and to contact HD and primary healthcare provider if symptoms worsen.

One week after the shot (1-14-2021) Patient (19 y.o.)reported side pain and appeared constipated, Laxatives given along with Tylenol, on further assessment Patient was noted to have left leg redness and abdominal fullness. Dr. was updated and we had orders for close monitoring, the next day when she got up, her leg appeared better, and she had passed a small BM, but by lunch she had developed significant pain and edema in her left leg, and the color of her leg was reddened again. She was sent to the emergency room with her symptoms. She was admitted back to our facility yesterday, her diagnoses included Acute provoked left external illiac, femoral, popliteal, and peroneal DVT. Elevated Factor II levels, Elevated APC resistant, May-Thurner Syndrome, history of developmental disabilities, fecal impaction and urinary retention - suspected related to her fecal impaction. Vascular surgery was consulted, and pt. was started on a heparin drip, and mechanical thrombectomy was needed for both legs due to multiple clots. She was started on Eliquis and Plavix, and thigh high compression stockings were ordered, ace wraps being used until these are supplied. Her Fecal impaction was addressed also and the urinary retention resolved.

About an hour after getting the second dose I started to need to urinate every hour and a half. the next morning it was the same but I couldn't urinate. I went to urgent care at around 12 and they diagnosed me with Acute Cystitis with Hematuria (a UTI). I have never had a UTI before, I'm not sexually active nor ever have been, and I know how to clean properly. urgent care prescribed me Cephalexin and Pyridium.

Patient received her second COVID vaccine (Moderna) on 06/21/21. She says 12 hours after her vaccine she developed nausea, vomiting, and low grade fever. The vomiting became persistent and patient developed severe flank pain. She was taken to an ER. 24 hours post vaccine. Patient says she was given IV boluses and Zofran which helped resolve the vomiting, she was discharged later the same day. Her fever lasted 4-5 days, t-max 100.0 with intermittent Tylenol dosing. Since discharge she says she continues to have consistent nausea but denies vomiting. She admits she has little appetite and has not felt hungry. She denies diarrhea. Her flank pain is "constant" and she felt it was starting to effect her bladder. Patient denies burning and stinging; however, describes back pain prior to voiding. She says she does not feel she can fully empty her bladder despite having urgency to do so. She denies gross hematuria. She says she does not feel well in general and has no energy. She feels her flank pain is becoming worse and Tylenol is no longer giving her relief. Her brother says the family wanted to ensure there was no complications involving her kidneys considering her history. The renal team did not feel patients symptoms were related to a kidney/bladder issue but rather a reaction to her second COVID vaccine. Her case was discussed with rheumatology and infectious disease. She received ondansetron for nausea, Naproxen for pain, and encouraged her to remain well hydrated. She was prescribed a short course of prednisone.

05 Feb 2021: Patient reports headache, fever, muscle aches and chills starting yesterday evening. Patient states that last night around 2200 became very confused, felt shaky for a brief period, had muscle soreness, sleepiness and confusion for around 30 minutes afterwards. Notes that she had drooled a lot and been incontinent of urine. This morning she continues to have flu like symptoms, appears alert and oriented over the phone. Patient is going to be escorted to Emergency room for eval.

Prior I had a UTI (undiagnosed a the time), then since taking the vaccine slightly over 24 hours later, I got severe lower left abdominal pain. I was admitted to the hospital with the severe pain, chills, fever. After a CT scan it was determined I had an inflamed bladder with severe bladder spasms.

I felt fine up until I went to bed at about 11 pm. I woke up at 2 am on the 20th of May feeling extremely fatigued and feverish. I took my temperature about an hour later and my temperature was 103.3 F. I experienced a racing heart rate and heart palpitations throughout the night alongside the fever. My temperature didn't lower until another 3 hours, in which I took Tylenol, used cold rags on the skin, and soaked in a cold bath to lower my temperature. My fever went up and down all day during the 20th, wherein I felt generally unwell and feverish. Today, the 21st, my urine is extremely dark and black tea-colored because of blood in my urine, due to a preexisting kidney disorder where blood spills into my urine whenever I contract a virus.

chest pain, low grade fever, chills/sweats, slight body aches, vomited all night long, hallucinations, and said her kidneys hurt. Pt did not go to the ER. Pts mother contacted me this AM via email. Pt better today with APAP PRN and rest

Around 10 min after injection patient flagged down a technician and said she thought she was going to faint. Fainting has happened to her in the past and she could feel it coming on. The pharmacist moved her closer to the area and gave her water. While pharmacist was standing with her she lost consciousness and control of her bladder. Pharmacist held patient upright as she was still in the chair as to not obstruct breathing. Patient was out for around a min and regained consciousness. Pharmacist in that time had called EMS who arrived later and checked all vitals. Patient drove alone nearly an hour so Pharmacist want to make sure she was ok before driving the long distance home.

Went to ER, then admitted to hospital with Mesenteric adenitis?not sure it?s related but wanted to pass on as doctor mentioned it could be as swollen lymph nodes seen in other areas after vaccine. Spent nights in hospital with sharp abdomen discomfort, decreased kidney function, nausea, vomiting.

I woke up with a very itchy and burning sensation in my private area. My mom suggested it was a uti, but I have never had one before and didnt do anything that could have caused it. Im better now, still leaking some urine. I have found 100s of women my age online who say they got their first ever uti after the covid vaccine, but I cant find any data on it as a possible effect.

Patient said she was feeling okay, however, patient then passed out. Shortly after passing out and losing consciousness, the patient started to have seizure like activity (extreme muscle rigidity in a spasm like way), with some vocal sounds. This continued for maybe around 1.5-2 minutes, and then patient regained consciousness. She wet her pants. Came to and felt extremely tingly everywhere. Looked extremely pale. Provided water, patient mentioned she hadn't eaten. Grabbed her a bar to snack on. EMS then arrived on the scene and took over care.

Got shot on a Tuesday 3pm, arm sore right away, full body aches appeared 12 hours after. I woke up Thursday morning with a left swollen labia minora and a stinging sharp pain wiping after urination, blood spots on TP. I took flash photos to see what it looked like at the entrance of my vagina. I saw a cluster of small, bleeding, open wound sores, looked like speckles of blood. I saw a doctor at Health Services the next morning and was told it looks like I have herpes. I did a viral culture swab for hsv. I had just tested negative for a full panel std test (minus hsv) in February, so we did not redo it. Monday, I got the call, my doctor said the results were negative and most likely a false negative, she said she is sure I have herpes. Tuesday, the next day I go into health services again to get a second opinion from another doctor and get re-swabbed. The second doctor agreed it looks just like herpes and she doesn't know what else it could be. We do another viral culture swab and she confirmed that she picked up fluid from the sores this time. I was also swabbed for gonorrhea and chlamydia and redid the full panel std blood test from February. The results all come back negative, and the doctor says she doesn't know what else it could be besides herpes. I am fed up with no answers and go to an urgent care. The doctor does not know what my lesions could be from. We did another viral culture swab that tests for gonorrhea and chlamydia and hsv. She offered pills to treat chancroid just in case and I took them thinking it was risk free. By the time I got home I was throwing up for a couple hours. My results come back negative. My second doctor calls me and says she is confident I could have syphilis (even though the sores were the most pain I've ever experienced). I came in to give blood for syphilis and hsv testing. Both came back negative, but the doctor was telling me I should still go somewhere for syphilis treatment (a shot I think?). I was even more frustrated. I sought out an OBGYN center that specializes in ulcers. The amazing doctor agreed with me that I do not have any std's and that my ulcers were a result of the vaccine. By this time the sores were healed.

-3 hours after my first shot I felt very disoriented and nauseated. I immediately fainted and I lost consciousness for 5 minutes, while unconscious I also was incontinent and peed myself. When I came to, I was disoriented for about 2 minutes and very cold. -For a week after I fainted I was very weak and couldn't stand up without feeling that I was going to faint. -The second week after my shot I also felt pressure on my chest for 5 days that has since then gone away. -Since I fainted 3 hours after my shot I have experienced constant ringing in both ears that have not stopped for the past 30 days since I got the vaccine. I also experience blurry vision and vertigo that hasn't gone away. -I have also developed headaches and recently I have an itchy rash on my neck. -Since then it has been hard for me to focus and sometimes I feel like the world is in slow motion.

4/15; 11:30AM - Left arm began to have intense pain around the injection site (up to the shoulder and down to the inner elbow). 4/15; 11:30AM-onwards - more frequent urination despite lack of drink intake 4/16; 7:30AM - began to experience severe headache, some nausea, and an increase of pain the left arm 4:16; 8:12AM - headache and nausea intensify, eyes begin to hurt and light and sound sensitivity develop, pain in left arm increases and the inner elbow of the right arm begins to mirror the left arm.

Approximately 10 minutes after vaccination the patient reported feeling "hot" and appeared lethargic. She lost consciousness, had mild full body tremors, and was unresponsive sliding down in her chair. She was pale and clammy. This lasted approximately 30 seconds. During this event she had urinary incontinence. She was assisted to a private area where she was given oral fluids and a snack. She was observed for more than one hour. During this time her VS's were WNL. The provider attending her stated the patient became anxious when the subject of leaving was brought up. She reported having anxiety with shots.

Grand mal seizure started within 1 minute of vaccine administration. Patient had full body stiffness, eyes rolled back, urinated herself, and had a brief loss of consciousness. Seizure spontaneously resolved within 10 seconds and patient had a several minute post-ictal phase. I rolled patient onto her side and monitored her O2 sat in the post-ictal phase. Patient reported dizziness and nausea during this period. EMS evaluated patient and recommended emergency evaluation, patient refused transport. Patient ambulated on her own out of the store after about 20 minutes.

Patient only had muffin and coffee that day early in am. Had some arm pain after shot no other reaction. Did go home felt some nausea . Did not throw up. Did not eat anything rest of day until around 11:30 pm . Felt much more nauseated and stomach cramping. Said she felt light headed and then had what appears to be vasovagal with brief passing out and then revived and with sweats. Was not confused . Did not loose continence. Was completely coherent after event. Went to ER to be checked out. In ER was found to have UTI and given some Rochephin . Had severe face and body swelling reaction requiring benadryl. Was observed and sent home after several hours. It was assumed that ER had reported this although it was felt by ER and us that this was vasovagal from not eating and nausea and UTI on top of that. Did not feel was secondary to vaccine . ER did not feel it was either. However while probably unrelated we felt should document it.

Symptoms began 9 hours after vaccine administration. Chills, fever, sore muscles, foggy brain, stuffy nose, cough, headache, frequent urination, nausea, anorexia. Still ongoing symptoms at 26 hours.

On Monday around 1:30 in the morning I woke up with a definite urgency to go to the bathroom. After I went I still felt like I had to go and It definitely felt like I had a UTI. I have not been sexually active in months. I went to my doctor the next day and when I took the urine sample I knew without a doubt that I definitely had a UTI from all the symptoms I was having we?re by the book. It ended up coming back that I did not have a UTI but my doctor still put me on the anabiotic?s. I then come to find out one of my coworkers who had her shot the day before me had the exact same thing happened to her and it just seemed worth reporting.

Kidney Pain, Liver pain, joint and muscle pain, increased skin sensitivity, out of breath, nausea all starting 12 hours passed injection time.

24yo F with hx of sulfa allergy received the Moderna Covid vaccine on 1/4. Day 1 felt chills, feverish. Reports edema in limbs, face, hands and whole body ("swollen to twice it's size). Tingly lips, extreme headache, nausea and body aches. Reddish urine for 4 days following. Swelling subsided after a few days.

Nausea, vomiting, fever of 102 for 5 days, chills, body aches, joint pain. Local reaction on day 7, itchy, swelling, hard lump, bright red, roughly 8 ×10 cm. Kidney pain

Patient began to have fevers/chills night after vaccine. Continued with fevers and night sweats. Exhausted during the day for a week. On day 6, patient reports feeling very thirsty, vertigo, fell, lost balance and use of extremities, loss control of bowels, and speech for period of about 20m. Taken to the ER where she was told she might have had a mild UTI that worsened after the vaccine. Was started on antibiotics.

Petechiae on arms/legs, bruising on legs/arms/back, headache, fatigue, general feeling of malaise, joint pain on first day, yellowing eyes, dark urine

fever of 102, unable to move, severe fatigue, chills, sweating, and having to urinate every hour for 8 hours straight for both first and second shot

poor oral intake . Seizures. on admission she was found to have lactic acidosis. Transaminase elevation and thrombocytopenia and Cr of 1.2

8 hours after vaccination: Bad headache, fever (100 degrees with tylenol), fatigue, fogginess, increased need to pee without increased liquid intake. Arm soreness. Next day: still feverish (100 degrees without tylenol), fatigue, mild headache, grogginess. Still arm soreness. Felt about 30% back to normal. Still increased need to pee. Day 3: About 75% back to normal, easily fatigued, continued arm soreness at touch. Day 4: Less easily fatigued, but about 90% back to normal, continued arm soreness but just movement based. Day 5: About 95% back, continued exhaustion/fatigue. Mild arm soreness, only movement based.